Identification of Candidate Proteins for an EEHV Vaccine

While significant progress has been made in diagnosing and treating EEHV hemorrhagic disease, a vaccine could provide a long-term solution. Dr. Paul Ling’s lab at the Baylor College of Medicine has established a test that can identify virus components that cause robust immune system responses in elephants.Studies in human herpesviruses have identified categories of proteins that induce immune responses that protect against the disease. Approximately 27 proteins encoded with a prototype EEHV1A genome fit into these categories. This study tested some of those proteins to identify which can induce the most robust immune response in elephants to identify a core set of EEHV proteins that would be part of a first generation EEHV vaccine.

IEF #EX1025

Project Years: 2017

Project Partners:
Dr. Paul Ling Baylor College of Medicine