Project Description

Ex Situ – Pharmacokinetics of Rectally and Orally Administered Levofloxacin in Asian elephants

When following established, husbandry protocols, tuberculosis in elephants is a manageable and treatable disease. Treatment requires a multi-drug regime, with primary and secondary medications. The current most commonly used secondary medication, enrofloxacin, has been clinically shown to have an increased incidence of side effects when dosages are increased to achieve therapeutic blood levels. Another antibiotic, levofloxacin, has been safely used in elephants as part of tuberculosis treatment but current dosage levels are based on experience. The Elephant Tuberculosis Stakeholder’s Task Force has identified the need for a pharmacokinetic study on levofloxacin in elephants. IEF is supporting this study to scientifically make recommendations on dosages for administering levofloxacin to achieve effective therapeutic blood levels, benefitting both the treatment of elephant tuberculosis as well as other bacterial infections.

International Elephant Foundation Strategy In Support Of Elephant Conservation

IEF-supported projects protect elephants from poaching, seek solutions for human-elephant conflict, equip and train community conservationists, increase our knowledge of the treatment and prevention of disease and educate people. In 2017, IEF will provide over $600,000 to support elephant conservation around the world, adding to the over $4 million total invested in conserving elephants since our inception in 1998. The following elephant conservation projects will receive support from IEF in 2017