Drugs that inhibit fibrinolysis, such as epsilon aminocaproic acid (EACA), are of increasing interest in human and companion animal medicine to prevent bleeding due to surgery, trauma, and other causes. EACA and related drugs have been associated with decreased mortality and decreased transfusion requirements in patients suffering from hemorrhage. These drugs may be especially valuable in elephants, as banked blood products are not available and therapeutic transfusions can be logistically challenging.

Scientists at Cornell University, College of Veterinary Medicine will use an in vitro model of hyperfibrinolysis to estimate the plasma level of EACA that effectively inhibits fibrinolysis in Asian elephant plasma. The results of this study will provide necessary groundwork for safely applying EACA in clinical situations in elephants decreasing morbidity and mortality due to hemorrhagic disorders, which include EEHV and reproductive tract disease.


The International Elephant Foundation Strategy in Support of Asian Elephant Conservation is the result of the International Elephant Foundation (IEF) facilitated workshop of technical representatives from U.S. Asian elephant facilities with expertise conserving Asian elephants in human care, and other U.S. representatives with expertise and experience conserving Asian elephants in range countries. The goal of this Action Plan is to enhance and conserve Asian elephant populations in the wild. Click Here to view/download detailed information.