EEHV Viral Genomics and Pathogenesis

The three most common and useful techniques for studying viruses are not applicable for EEHV. However studying the genomes of EEHVs by PCR amplification and DNA sequencing directly from necropsy tissue and other clinical samples provides information about the genetic make-up of each virus and about the genes and pathways that they utilize to take control of particular types of host cell. That information allows us to generate additional clinical reagents such as specific antibodies and target antigens, as well as cloned expression vectors for viral enzymes that can be used in laboratory research and pathological diagnosis. The ultimate goal is to identify viral immediate-early genes, latency genes and immune evasion genes and other potential novel viral genes or pathways that will provide insights into the mechanisms of viral pathogenesis and will also help for generating engineered attenuated vaccine strains or new targets and approaches for better antiviral drugs.

IEF #EX1020

Project Years: 2013 – 2022

Project Partners:
Dr. Gary Hayward, Johns Hopkins University